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However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind

This study demonstrated that PSSI 90 and PSSI 100 results were maintained until week 60 in patients initially treated with ixekizumab 2-week dosing who were switched to 4-week dosing schedules (79.1% and 75.9%) as well as patients continued on a ixekizumab 4-week dosing schedule (76.2% and 73.6%) [45]

J Transl Med 20(1):452