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Upper and lower lip and snout edema, as well as extreme cyanosis and edema of paws and scrotum were markedly attenuated

The engineered hiPSC-MSCs successfully delivered GPx3 to the liver and ameliorated hepatic injury by inhibiting hepatic senescence [117]

Furthermore, the upregulation of transforming growth factor (TGF)- and WNT signaling pathways promotes the activation of SNAIL and DLX2, which in turn upregulate the expression of GLS [112]