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In vitro experiments Cell culture studies Biochemical research protocols Approved preclinical research models All usage must comply with institutional research guidelines, ethical approvals, and applicable regulatory requirements

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Preclinical PTSD models consistently implicate gut barrier dysfunction, immuneinflammatory activation, HPA axis dysregulation and neurotransmitter imbalance as key mechanistic through-lines (Sherin and Nemeroff, 2011

This raises the possibility that if a patient ingests some iron supplement tablets during a suicide attempt with an overdose of APAP [83, 84], the mechanism of cell death is switched to ferroptosis, and the accelerated and enhanced severe toxicity can be rapidly fatal [85]