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Reviews in Endocrine & Metabolic Disorders

Chronic use of these substances is strongly associated with persistent cognitive deficits, psychiatric symptoms, and, in some cases, neurovascular damage

Explored as a possible aid for recovery and lean-mass preservation in frail or catabolic populations, though a Merck-sponsored Phase 2b trial in elderly hip-fracture patients (Adunsky et al., 2011, Archives of Gerontology and Geriatrics, PMID 21067829) was halted early over a cardiac safety signal rather than demonstrating a clear functional benefit

Potential Side Effects and Considerations Vitamin B12 is generally safe at recommended doses, but side effects like headache, nausea, or stomach upset can occur with high-dose supplementation