Lipoic acid is a well-known antioxidative agent that can be used clinically to treat DM and neurodegenerative diseases, closely related to reducing the risk of occurrence of complication and mortality (Singh and Jialal, 2008
112 Moreover, YAP, a crucial transcriptional co-activator, also undergoes lactylation and enhances its nuclear localization and subsequent interaction with TEAD, thereby collectively promoting the expression of Hippo pathway target genes
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