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The literature on KLOW peptides specifically is sparse compared to larger compound classes, but the pharmacokinetic principles are consistent across peptide families: molecular weight, lipophilicity, and mechanism of action determine optimal route far more than arbitrary preference

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Inhibiting these enzymes promoted remyelination in vivo by depleting toxic 8,9-unsaturated sterol intermediates, which otherwise block oligodendrocyte maturation [90, 91]

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