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Given the small number of patients studied, the invasiveness of the procedure, and the lack of long-term follow-up data on a sufficient number of patients, the Panel judged that sacral/pudendal neurostimulation may be effective in carefully selected patients and this decision should be left to the individual clinician and patient

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The endothelium, the inner lining of blood vessels, plays a vital role in maintaining vascular homeostasis by regulating vasodilation, blood flow, and platelet aggregation [65]

however, excessive ROS production can disrupt cellular balance and lead to oxidative stress