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Description

At about 40 years of age, practically all patients with Down syndrome exhibit neuropathological changes typical for Alzheimers disease including -amyloid plaques and neurofibrillary tangles (Mann and Esiri 1989)

Association with efficacy was done with the confirmed objective response

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Therapeutic response to cyanocobalamin may decrease due to elderly age, infection, renal insufficiency, diabetes mellitus, marrow suppressants use (e.g