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The Loading Dose The updated GrassrootsHealth Vitamin D*calculator calculates a customized loading dose to help an individual reach their chosen target vitamin D level more rapidly (based on body weight and starting vitamin D level) allowing you to reach your target level within days instead of over three months

28, 30 Colchicine plasma concentrations can be doubled by concomitant CYP3A4 inhibitor use and quadrupled by concomitant P-glycoprotein inhibitor use

The most appropriate route depends on the specific research application

However, your specific schedule will depend on your individual response to treatment and any symptoms you may experience