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In more recent studies, serum vitamin E levels were predictive of hemorrhagic events, especially in vitamin K-deficient patients (one interventional study on 12 cardiology patients receiving long-term warfarin, with mild-to-moderate prothrombin times (range, 16.021.5 s), and one retrospective observational study on 566 consecutive patients) [305,306] (Table 2)

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It was first identified in human plasma and has since become a major subject of interest in regenerative biology, tissue engineering, and extracellular matrix research