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Inflammation Production of inflammatory mediators Chronic inflammation is acknowledged as a pivotal factor that propels the transformation of epidermal cells and their progression towards malignancy [121, 122]

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D

The utilization of available oxygen by mitochondria, which are present only at the periphery, appears to be responsible for maintaining the gradient and the very low oxygen level in the nucleus