Ketosis is the result of starvation or semi-starvation, with the latter (i.e., a very low-calorie ketogenic diet, VLCKD) being used for weight loss purposes in obesity and other metabolic diseases ( Each dietary therapy has advantages and disadvantages, i.e., the classical protocol reaches the maximum level of blood ketosis but might induce long-term side effects due to compensated acidosis, which is a hallmark of the therapy
In particular, to recapitulate the proliferative phase, organoids are exposed to an estrogen receptor (ER) agonist (typically E2), while a combination of E2 with a progesterone receptor (PGR) agonist (typically P4 or medroxyprogesterone acetate (MPA)) and decidualization-promoting cyclic adenosine monophosphate (cAMP) is employed to replicate the transition to the secretory phase [53, 54, 63]
Only a small portion (10% to 25%) binds to proteins in the blood, allowing most of the drug to be available for pain relief and fever reduction, as explained by Gerriets et al
PMID: 36089905
