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3rd & Brookeman, J

diffuse axonal injury (more than three lesions) depending on the severity of the impact ( Cognitive impairmentsparticularly persistent memory deficitsare among the most frequently reported long-term consequences of TBI ( The disruptions to the dopamine and noradrenaline networks due to TBI are fairly common ( Our group has recently published findings on the use of guanfacine, an alpha-2A noradrenergic agonist, for treating patients with mild TBI who exhibit deficits in working memory and executive functioning ( NAC is a potent antioxidant which replenishes glutathione levels and has demonstrated mitochondrial protective effects ( Donepezil, a cholinesterase inhibitor, is FDA-approved for the treatment for of mild cognitive impairment due to Alzheimer's disease ( Given the widespread neuroanatomical and neurocircuitry disruptions observed in severe traumatic brain injury (sTBI) and the associated global neurocognitive impairmentsincluding deficits in working memory, executive functioning, and verbal and episodic memorythere is a strong rationale for the synergistic clinical benefits of combining guanfacine and donepezil

In lung cancer, however, the CHAC2-mediated increase in ROS triggers the MAPK pathway

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