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Concerning to cancer pain, a phase I clinical trial is being carried out to determine the efficacy of periganglionic/intrathecal administration of the potent TRPV1 agonist resiniferatoxin in advanced cancer patients with bone pain (Clinical Trials, Conclusions NP is an underestimated socioeconomic health problem affecting millions of people worldwide, which incidence may increase in the next years due to chronification of several diseases such as cancer and diabetes

Altogether, these experimental data reveal that circadian disruption affects multiple BC-related hallmarks including immunosuppression, chronic inflammation, altered hormone receptor expression, and dysregulated cell proliferation 204

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