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[41] showed that Th1 cytokine IL-12 significantly decreased the protein expression of 7 nicotinic acetylcholine receptors (7 nAChR), which was expressed on murine CD4+ T cells and relayed anti-inflammatory signals, while Th2 cytokine IL-4 enhanced 7 nAChR expression

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This makes it harder to know how much nicotine may be delivered to the body

The alcohol use disorder and associated disabilities interview schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample