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Understanding the transport of GSH across the plasma membrane is an important issue that is essential to treatment of diseases involving oxidative stress (see reviews by Ballatori et al., 2008 and by Yuan and Kaplowitz, 2008 in this issue)

In conclusion, via experiments in Nrf2 -knockout mice, we demonstrate that pyridoxine can induce GSH biosynthesis through the PKM2/Nrf2 pathway

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