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Likewise, due to the large presence in human fetuses and adult tissues (in situ hybridization and immunostaining) [14], the concept holds a regulatory physiologic role in bodily functions [14], also based on similar beneficial effects in other species (i.e., birds [73] and insects [74,75,76])

Nevertheless, the specific amino acid composition and sequence of the peptide determine its physicochemical characteristics as well as its pharmacokinetics and pharmacodynamics