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Although uterine expression levels of estrogen receptor , G protein-coupled estrogen receptor, and steroid synthase were upregulated in the high-dose group, the decreased expression of connexin 43 and alkaline phosphatase as well as the increased expression of insulin-like growth factor-binding protein three and monoamine oxidase were consistent with decreased estrogen signaling and lower uterine weights

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Chelating zinc leads to an inhibition of both LPS- and IFN--mediated increases in STAT1 mRNA expression in RAW 264.7 macrophages [242]

Above mentioned shelf life is applicable when product is stored under optimum conditions otherwise it can get expired before mentioned period