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10.1002/mds.27115 348 ObrenovichM.JaworskiH.TadimallaT.MistryA.SykesL.PerryG.et al

Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-B, p53, ERK, and JNK in proximal tubular cells

New strategies for the development of antifungal drugs have gradually become a research hotspot, including the targeting of novel biological pathways, the combination of antifungal drugs, the development of fungal vaccines, the creation of innovative therapeutics (such as small-molecule peptides and nanoparticles), the extraction of active ingredients from traditional Chinese medicine, and the utilization of artificial intelligence in drug design ( Figure 1 ) (Wall and Lopez-Ribot, 2020

A study found that low-dose QUE combined with PTX had more potent inhibitory effects on the proliferation, cell cycle, and migration of PC-3 prostate cancer cells than PTX alone, whereas this combination promoted apoptosis (70)