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Upon reception of a signal to migrate such as chemical mediators called chemokines present near the edge of the wound the bound pool of actin monomers becomes immediately available to form actin filaments in the lamellipodium and filopodia of migrating cells

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Medical Pharmacology Chapter 2 General Principles: Pharmacokinetics Clinical Pharmacokinetics Introduction Pharmacokinetics in Therapeutics Pharmacokinetics (PK) is the scientific discipline dedicated to the quantitative study of the time course of a drug's absorption, distribution, metabolism, and excretion (ADME) within a living organism