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The activation of TLRs causes conformational changes in the TIR domain and allows the recruitment of cytoplasmic adapter proteins such as TIR domain-containing adaptor protein (TIRAP, MAL), myeloid differentiation primary response protein MyD88 (MyD88), TIR domain-containing adapter-inducing interferon- (TRIF, TICAM1) and TRAM that anchor the TIR domain

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