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To test whether plasma purine and monoamine metabolite concentrations were correlated in SZ, we studied previously published measurements (Yao et al., 2010a, b) of six purine metabolites (Hx, Xan, Xant, G, Gr, UA) for which concomitant measurements of 14 monoamine metabolites, tryptophan (TRP), serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindoleacetic acid (5-HIAA), tryptamine (TRPA), melatonin (MEL), kynurenine (KYN), 3-hydroxykynurenine (3-OHKY), tryptophol (TPOL), tyrosine (TYR), L-3,4-dihydroxyphenylalanine (L-DOPA), Normetanephrine (NMET), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA), were also available from HC ( n = 30) and FENNS-BL ( n = 25) and FENNS-4w ( n = 25)

On the opposing side, PhRMA, the Partnership for Safe Medicines, and the American Pharmacists Association each filed against inclusion of all seven substances, with the Partnership for Safe Medicines specifically flagging reports of Chinese manufacturers who previously produced fentanyl precursors now pivoting into peptide sales