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46,47 In addition, the CTD is necessary for contact with negative regulators (MDM2/4) and to induce many posttranslational modifications, such as acetylation, phosphorylation, methylation, and ubiquitination, which adjust its functionality and stability

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The cell culture medium was changed daily until the cells reached a confluence of ~1.5-3.0x105 cells/cm2, which generally occurred 3-4 days post passage

Three active peptide compound Glutathione (Glutathione, GSH) is made up of glutamic acid, cysteine and glycine by peptide bonds condensation of three peptide compounds, chemical name called gamma-L-glutamine-L-in ammonia acyl-glycine, its structural formula is shown in figure 1