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Aging brings about a natural reduction of collagen production, resulting in the accumulation of deeper lines and wrinkles

This inflammation is a result of the body's immune response to the bacteria and debris trapped within the clogged pore, which can lead to further irritation if not treated properly

Mast cells (the cells which secrete histamine) also bridge communication between the immune and nervous systems by producing neurotransmitters and other mediators, such as NGF, serotonin, Substance P, and nitric oxide

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society , 9 (2), 106113