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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

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Unlike full-length human growth hormone, which binds to growth hormone receptors throughout the body and triggers widespread effects, AOD-9604 acts primarily on adipose tissue through a distinct receptor mechanism