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The mammalian lipoxygenase family includes six distinct isoforms (ALOXE3, ALOX5, ALOX12, ALOX12B, ALOX15, and ALOX15B), and the researchers found that only the absence of ALOX12 significantly reduced ferroptosis

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Conversely, Gotthard and colleagues showed that in a model of murine lymphoma (26), STAT-5-deficient NK cells expressed elevated levels of VEGF and were able to induce endothelial cell sprouting ex vivo

This broad spectrum of activity makes GHK-Cu a molecule of significant interest in preclinical studies related to dermatology, regenerative medicine, and cellular senescence