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3 Gut microbiota-derived SCFAs 3.1 The overview of intestinal flora The intestinal microbiota has a large number of 10 trillion or even 100 trillion microorganisms, including bacteria, fungi, and viruses (67, 68), and the development of high-throughput sequencing technology has revealed that the gut flora contains far more genes than the human genome, leading to the term second human genome (69)

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FIGURE 2 In contrast, with the administration of L-NAME, there was a moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc, faint presentation of the choroidal blood vessels appears immediately, and these lesions (Figure 2, IN, IIN) rapidly progress (Figure 3, AC

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