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NF-B then drives transcription of pro-inflammatory cytokines and chemokines, while AP-1 up-regulates genes encoding cytokines, enzymes and factors involved in leukocyte activation and tissue remodelling 11

Non-clinical research literature focuses on endocrine signaling frameworks, receptor interaction behavior, and molecular pathway exploration under controlled laboratory conditions

10.3390/cells10092340 85 MartinN.ElenaP.HannesG.MartinF

Therefore, nutraceutical skin applications using collagen and antioxidants such as curcumin and glutathione demonstrate hopeful results for dermal antiaging effects, especially in estrogen-deficient skin