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Besides disruption of liver histoarchitecture (including vascular dilation and congestion), hepatocyte degeneration, increased serum AST and alanine aminotransferase (ALT) levels, enhanced oxidative stress, and pronounced infiltration of inflammatory cells accompanied by upregulation of pro-inflammatory genes were observed [151]

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While there are chemotherapeutic treatments available for many diseases, they are not sustainable on their own due to high rates of reinfection, risk of drug resistance, and inconsistent management of drug treatment programs