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November 25 Product: Shorla Oncologys Imkeldi Indication: Several forms of leukemia and other cancers The FDA on Monday signed off on Shorla Oncologys Imkeldi, an oral solution indicated for the treatment of certain types of chronic myeloid leukemia and acute lymphoblastic leukemia, as well as other cancers such as myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis and dermatofibrosarcoma protuberans

Recommendations Further clinical trials are needed to validate dosage regimens and efficacy in diverse populations

After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)