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Current regulatory frameworks often handle nanomaterials under general chemical safety regulations with case-by-case additional requirements, and comprehensive environment-safety-health (ESHS) standards for complex multifunctional platforms are not yet fully developed [89, 114]

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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies