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NSG mice were purchased from The Jackson Laboratory (Sacramento, CA USA) and maintained in microisolator cages in appropriate sterile conditions, which include autoclaved cages, bedding, nestlets, and igloos along with irradiated food and filtered water

Statistical analyses Medians and 25th and 75th percentiles (interquartile range, IQR) of salivary cotinine concentration were computed according to the different strata of the potential modifiers

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