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12 GSH serves as a substrate for 2 antioxidant enzymes: GSH peroxidase and phospholipid hydroperoxide GSH peroxi-dase

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According to this study, oligodendrocyte apoptosis is caused by TNF and IL-1, released due to the fractalkine receptor chemokine receptor 1 (CX3CR1) and its ligand (CX3CL1) axis and the p38MAPK pathway (for more detail, see Wu et al., 2016)