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Also, 30- to 40-year follow-up data from the International Childhood Cardiovascular Cohort Consortium have revealed consistent links between childhood obesity and early mortality from cardiovascular diseases, cancers, abnormal lipid metabolism and diabetes in adulthood [233,234,235,236] Nonetheless, the seven cohorts in this consortium reside in high-income countries (US, Australia and Finland), thus, critical data from middle- and lower-income countries are lacking [237]

91 Although autophagosomes are often increased in MASLD, reductions in BECN1 and accumulation of p62/SQSTM1 indicate defective lysosomal degradation and impaired autophagic flux.1, 92 This dysfunction affects lipophagy, insulin signaling, inflammatory responses, and cellular stress pathways