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Acta Pharmacol Sin 26:799805 Zhou SF, Wang LL, Di YM, Xue CC, Duan W, Li CG, Li Y (2008) Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development

In view of the numerous papers showing the inverse relationship between low concentrations and various diseases, and although a reliable threshold concentration has not yet been defined, numerous therapeutic strategies to increase bilirubin to moderate concentrations and strategies to promote stronger antioxidant, anti-inflammatory or immunomodulatory effects have already been considered in the literature

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10.3390/ijms241914667 180