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Its a query that doesnt have a simple, single answer, as the duration of a B12 shots effects can vary significantly from one person to another

The largest Phase 2b trial (502 participants, 24 weeks) did not show statistically significant weight loss versus placebo

Tirzepatide monotherapy produces substantial weight reduction in clinical trials, and any perceived benefits from combination use likely reflect tirzepatide's pharmacological effects rather than synergistic action

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