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This model helps explain the multisystem pattern of fatigue, tachycardia, cognitive dysfunction, flushing, and GI disturbance seen in Long COVID

This HO, though less reactive, is still potentially harmful and is further detoxified by CAT and GSH-Px, which break it down into water and oxygen, reducing its potential for cellular damage

Anxiety can deepen the same loop, since excessive worry often brings muscle tension, restlessness, and trouble concentrating, symptoms detailed by the Mayo Clinic in its guide to generalized anxiety disorder

2012 (PMID 22129598), which introduced the HGF-dimerization framing, was retracted in 2025 (retraction notice PMID 40312092)