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Effective functional metabolites of tobacco including nicotine, solanesol, seed oil containing high unsaturated fatty acids and linoleic acid, and leaf extracts mainly containing chlorogenic acid, kaempferol 3-O-rutinoside, p-hydroxybenzoic acid and rutin have emerged in many disease fields, especially in some difficult diseases: cranial nerve diseases including Alzheimers disease, Parkinsons disease, Huntingtons disease, intracerebral and ventricular hemorrhage, autism, and bipolar disorder