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Most research examines acute effects over days to weeks, not chronic exposure over months or years

The state of hepatic GH resistance in anorexia nervosa is further corroborated by the lack of increase in IGF-I following administration of supraphysiological doses of exogenous GH in women with anorexia nervosa (61), and only refeeding appears to able to restore IGF-I levels (56, 59, 62)

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After an initial loading phase, some patients maintain with monthly injections