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First generation deficient animals are more sensitive to stresses, especially when also deficient in vitamin E, and more sensitive to toxicity of certain chemicals and heavy metals such as mercury

On top of that, selenium connects with thyroid and testosterone to influence hormone production

doi: 10.1016/j.jss.2023.08.056 48 KariyamaKNousoKHiraokaAWakutaAOonishiAKuzuyaTet al

[1] That is the archetype of translational success: a defined molecule, a defined indication, a measurable endpoint (visceral fat), and confirmatory randomized trials