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Methylcobalamin helps reduce homocystein concentration by converting homocysteine to methionine through a methylation process

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Indeed, the increased thrombotic risk caused by hyperhomocysteinemia, recently reviewed by D'Angelo and Selhub (1997), seems to be independent of the conventional risk factors including protein C, protein S, and antithrombin III deficiencies

In this review, we summarize the important role of melatonin in the damaged mitochondria elimination and mitochondrial energy supply recovery by regulating mitochondrial quality control, which may provide new strategies for clinical treatment of mitochondria-related diseases