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Animal experiments have shown that rats treated with IGF-1 LR3 (0.3 mg/kg/d) for 8 consecutive weeks have a 2-fold increase in fasting insulin levels and a 1.8-fold increase in HOMA-IR index

The top 10 most significantly altered canonical pathways are demonstrated in Table 2 (with all significantly altered pathways displayed in Supplementary Table S1 )