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The probe was based on polyglycerol scaffold which consisted of a fluorescent donor dye indocarbocyanine (ICC) and an acceptor indodicarbocyanine (IDCC) dye linked in proximity through a pH-labile hydrazone bond (Fig

A scientific review published in the National Library of Medicine in 2022 found that nose-to-brain delivery of therapeutic peptides is a non-invasive and fast-acting method that can effectively bypass the blood-brain barrier while minimizing systemic exposure

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For self-administered research protocols, oral dosing reduces training burden and protocol deviation rates