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There is no published GLP repeat-dose toxicology study in two species, no genotoxicity battery, no reproductive-toxicity data, no carcinogenicity study, and no published Phase 1 dose-escalation safety profile in humans meeting contemporary regulatory standards

Dosing & Reconstitution Guide Educational guide for reconstitution and weekly dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Route: Subcutaneous injection

64 However, several studies have found no association between synthetic incretins and NAION, and a recent review concluded that no definitive causal relationship has been established between these agents and NAION