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Canada regulations for the sale and marketing of vapes is stricter in Canada than in the UK and varies between different provinces, plus products are age restricted to over 19s only Denmark Estonia Japan the sale and supply of nicotine-containing e-liquids is not permitted, but nicotine-free vapes are readily available

Evidence indicates that long-term smoking substantially raises the risk of CAD and is linked to poorer outcomes in those already suffering from the disease ( 52 )

Minimizing \(\mid\mid t\mid\mid_0\) subject to constraints is a computationally complex optimization problem