nadph reduced glutathione homeostasis in cancer: functions, mechanisms and therapeutic implications Nicotinamide adenine dinucleotide phosphate -

2015;56:S29S45

Conventional therapies such as corticosteroids and immunomodulators often exhibit limited treatment specificity, potentially leading to systemic adverse effects while requiring progressively increased dosages to maintain efficacy

MALT1 hydrolase, located upstream of the Gln degradation pathway promoting GLS1-mediated Gln catabolism via c-Jun1, promoted epigenetic modification of H3K9Ac and H3K27Ac of the IL17A gene promoter, enhancing the chromatin accessibility of RORt (RORC), thus exacerbating IL-17A expression and ultimately causing immune peripheral blood imbalance and psoriatic lesions (79)

Archived from the original on 27 March 2019