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Decreased quinolinic acid in the hippocampus of depressive patients: evidence for local anti-inflammatory and neuroprotective responses

Thus, folate builds up in the form of 5mTHF (the "methyl trap") and there is less folate in the forms CH 2 -THF and 10f-THF that are the substrates for thymidylate and purine synthesis, respectively

We conclude that changes in the redox status of astrocytes could dramatically modify Ca 2+ responses to Gq-linked GPCR activation in both directions, by impacting store-dependent Ca 2+ -channels, and thus modify cellular excitability under purinergic stimulation