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Pernicious anemia is associated with an increased incidence of carcinoma of the stomach, but this is believed to be related to the underlying pathology and not to treatment with cyanocobalamin

Bone Fractures In 2019, a study found an association between high intakes of vitamins B6 and B12 from food and supplements with the risk of hip fracture among postmenopausal women in the Harvard Nurses Health Study