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Disclosure of interest: Nothing to disclose E-Posters - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.07 - SMALL VESSEL DISEASE P2397 - ESOC25-1825 GENOMICS OF NEW AUTOMATED DIFFUSION IMAGING MARKER SHEDS LIGHT INTO LIFESPAN DETERMINANTS OF CEREBRAL SMALL VESSEL DISEASE Yasaman Saba 1 , Hideaki Suzuki 2 , Pauline Maillard 3 , Michelle Luciano 4 , Ilana Caro 1 , Marco Duering 5 , Joanna Wardlaw 6 , Sudha Seshadri 7 , Lenore Launer 8 , Helena Schmidt 9 , Vilmundur Gudnason 10 , Paul Matthews 11 , Monique Breteler 12 , Aniket Mishra 1 , Stphanie Debette 1 1 University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France, 2 Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan, 3 Department of Neurology, University of California, Davies, United States, 4 Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom, 5 Medical Image Analysis Center (MIAC AG) and Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 6 UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, Edinburgh, United Kingdom, 7 Glenn Biggs Institute for Alzheimers and Neurodegenerative Diseases, University of Texas Health Sciences Center, St Antonio, United States, 8 Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Baltimore, United States, 9 Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria, 10 Icelandic Heart Association, Kopavogur, Reykjavik, Iceland, 11 UK Dementia Research Institute, London, London, United Kingdom, 12 Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Background and Aims: Peak width of skeletonized mean diffusivity (PSMD) has been proposed as a novel diffusion imaging marker for cerebral small vessel disease (cSVD), a leading cause of stroke and dementia with no mechanism-based treatments
In addition to its aesthetic benefits, some clients explore this therapy as part of a broader wellness strategy, seeking its supportive effects on liver function and overall vitality
For comparison, a multi-dose treatment with Nrf2 activators such as isothiocyanate-containing broccoli seeds, sulforaphane, erucin, or else the potent sulforaphane analog 6-methylsulfinylhexyl isothiocyanate, was needed to achieve similar levels of induction in the cytosolic fraction of liver in adult mice, i.e
