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The American Academy of Neurology guidelines recommend using melatonin, starting with a low-dose, for children and adolescents with autism spectrum disorder and sleep disturbance if behavioral strategies have not been helpful, and if contributing coexisting conditions and use of concomitant medications have been addressed (60)

Lai W, Yu L, Deng Y

The excessive accumulation of lipid reactive oxygen species (ROS) leads to destroying the cell membrane, leading to cell death [12]

Although LA is targeted specifically to the GI tract due to its nonabsorbed nature, understanding how long various formulations of the drug take to reach specific regions within the small intestine and in therapeutically effective concentrations are crucial for its use in other clinical conditions